{"id":5880,"date":"2022-08-24T07:22:26","date_gmt":"2022-08-24T05:22:26","guid":{"rendered":"https:\/\/www.msd.ch\/en\/?page_id=5880"},"modified":"2024-07-16T07:21:01","modified_gmt":"2024-07-16T05:21:01","slug":"lyfnua-publication-of-clinical-trial-results","status":"publish","type":"page","link":"https:\/\/www.msd.ch\/en\/lyfnua-publication-of-clinical-trial-results\/","title":{"rendered":"Lyfnua &#8211; Publication of clinical trial results"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">Publication of clinical trial results<\/h1>\n\n\n\n<p>The information given below and the relevant links to the clinical data fulfil the requirements of Articles 71-73 of the Ordinance on Therapeutic Products (Therapeutic Products Ordinance, TPO). They supplement the information published in association with the Swiss marketing authorisation for the medicinal product.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">LYFNUA\u00ae<\/h2>\n\n\n\n<p>Lyfnua\u00ae (Gefapixant), film-coated tablets, 45 mg<\/p>\n\n\n\n<p>Swissmedic Zulassungsnummer: 68065<\/p>\n\n\n\n<p>Date of Marketing Authorisation: 24-May-2022<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><br><strong>Clinical Trials<\/strong><\/h4>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>1.&nbsp; COUGH-1 (Protocol 027)<\/strong><\/h4>\n\n\n\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03449134?term=gefapixant&amp;draw=3&amp;rank=16\">A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-027) \u2013 ClinicalTrials.gov<\/a><br>NCT03449134<\/p>\n\n\n\n<p><strong>Publications<\/strong>:<br>McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J, Nguyen AM, Li Q, Tzontcheva A, Iskold B, Green SA, Rosa C, Muccino DR, Smith JA; COUGH-1 and COUGH-2 Investigators. Efficacy and safety of gefapixant, a P2X(3) receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials. Lancet. 2022 Mar 5;399(10328):909-923. doi: 10.1016\/S0140-6736(21)02348-5.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>2. COUGH-2 (Protocol 030)<\/strong><\/h4>\n\n\n\n<p><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03449147?term=gefapixant&amp;draw=3&amp;rank=19\">A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030) \u2013 ClinicalTrials.gov<\/a><br>NCT03449147<\/p>\n\n\n\n<p><strong>Publications<\/strong>:<br>McGarvey LP, Birring SS, Morice AH, Dicpinigaitis PV, Pavord ID, Schelfhout J, Nguyen AM, Li Q, Tzontcheva A, Iskold B, Green SA, Rosa C, Muccino DR, Smith JA; COUGH-1 and COUGH-2 Investigators. Efficacy and safety of gefapixant, a P2X(3) receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials. Lancet. 2022 Mar 5;399(10328):909-923. doi: 10.1016\/S0140-6736(21)02348-5.<\/p>\n\n\n\n<p><sup>CH-OGM-00002, 07\/2024<\/sup><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publication of clinical trial results The information given below and the relevant links to the clinical data fulfil the requirements of Articles 71-73 of the Ordinance on Therapeutic Products (Therapeutic Products Ordinance, TPO). They supplement the information published in association with the Swiss marketing authorisation for the medicinal product. LYFNUA\u00ae Lyfnua\u00ae (Gefapixant), film-coated tablets, 45 [&hellip;]<\/p>\n","protected":false},"author":282,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"bdl_company_name":[],"bdl_item_external_link":[],"editor_notices":[],"footnotes":""},"class_list":["post-5880","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.9.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Lyfnua - Publication of clinical trial results - msd.ch<\/title>\n<meta name=\"description\" content=\"Publication of clinical trial results for Lyfnua\u00ae (gefapixant), which was approved by Swissmedic on May 24, 2022.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.msd.ch\/en\/lyfnua-publication-of-clinical-trial-results\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lyfnua - Publication of clinical trial results - msd.ch\" \/>\n<meta property=\"og:description\" content=\"Publication of clinical trial results for Lyfnua\u00ae (gefapixant), which was approved by Swissmedic on May 24, 2022.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.msd.ch\/en\/lyfnua-publication-of-clinical-trial-results\/\" \/>\n<meta property=\"og:site_name\" content=\"msd.ch\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-16T05:21:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.msd.ch\/en\/lyfnua-publication-of-clinical-trial-results\/\",\"url\":\"https:\/\/www.msd.ch\/en\/lyfnua-publication-of-clinical-trial-results\/\",\"name\":\"Lyfnua - Publication of clinical trial results - msd.ch\",\"isPartOf\":{\"@id\":\"https:\/\/www.msd.ch\/en\/#website\"},\"datePublished\":\"2022-08-24T05:22:26+00:00\",\"dateModified\":\"2024-07-16T05:21:01+00:00\",\"description\":\"Publication of clinical trial results for Lyfnua\u00ae (gefapixant), which was approved by Swissmedic on May 24, 2022.\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.msd.ch\/en\/lyfnua-publication-of-clinical-trial-results\/\"]}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.msd.ch\/en\/#website\",\"url\":\"https:\/\/www.msd.ch\/en\/\",\"name\":\"msd.ch\",\"description\":\"MSD researches and develops medicines and vaccines to save lives and improve patients&#039; health. 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